The COMET (Core Outcome Measures in Effectiveness Trials) Initiative brings together people interested in the development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’. These sets represent the minimum that should be measured and reported in all clinical trials of a specific condition, and are also suitable for use in clinical audit or research other than randomised trials. The existence or use of a core outcome set does not imply that outcomes in a particular trial should be restricted to those in the relevant core outcome set. Rather, there is an expectation that the core outcomes will be collected and reported, making it easier for the results of trials to be compared, contrasted and combined as appropriate; while researchers continue to explore other outcomes as well. COMET aims to collate and stimulate relevant resources, both applied and methodological, to facilitate exchange of ideas and information, and to foster methodological research in this area.
Search COMET database
The COMET database currently contains 261 references of planned, ongoing and completed work.
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We maintain a BMJ blog about COMET activities and outputs. Our most recent blog is shown below:
Development of a core outcome set for bariatric surgery
James Hopkins and Jane Blazeby
Wednesday 01 August, 2012
Monday 29 April, 2013 - The COMET Workshop, 3 April 2013, Kyoto, Japan
Earlier this month, Paula, Liz and Mike were delighted to run the first COMET workshop in Japan, at Kyoto University, alongside Professor Toshiaki Furukawa (Professor and Chair, Department of Health Promotion and Human Behaviour Professor, Department of Clinical Epidemiology, Kyoto University) and Dr Rintaro Mori (Head, Department of Health Policy National Centre for Child Health and Development, Tokyo).
Thursday 18 April, 2013 - Can a core outcome set improve the quality of systematic reviews?
We investigated the amount of missing patient data for primary outcomes in Cochrane systematic reviews, and surveyed the Co-ordinating Editors of Cochrane Review Groups (CRGs) on issues related to the standardization of outcomes in their CRG's reviews. In one fifth of the 283 reviews in the sample, more than 50% of the patient data for the primary outcome was missing. Responses to the survey were received from 90% of Co-ordinating Editors. Thirty-six percent of CRGs have a centralized policy regarding which outcomes to include in the SoF table and 73% of Co-ordinating Editors thought that a COS for effectiveness trials should be used routinely for a SoF table.
Friday 11 January, 2013 - SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
To help improve the content and quality of protocols, an international group of stakeholders developed the SPIRIT 2013 Statement (Standard Protocol Items: Recommendations for Interventional Trials). The SPIRIT Statement provides guidance in the form of a checklist of recommended items to include in a clinical trial protocol. http://www.spirit-statement.org/
“Where possible, the development and adoption of a common set of key trial outcomes within a specialty can help to deter selective reporting of outcomes and to facilitate comparisons and pooling of results across trials in a meta-analysis. The COMET (Core Outcome Measures in Effectiveness Trials) Initiative aims to facilitate the development and application of such standardised sets of core outcomes for clinical trials of specific conditions (www.comet-initiative.org). Trial investigators are encouraged to ascertain whether there is a core outcome set relevant to their trial and, if so, to include those outcomes in their trial. Existence of a common set of outcomes does not preclude inclusion of additional relevant outcomes for a given trial.”
Blinding of outcomes in trials of orthopaedic trauma: an opportunity to enhance the validity of clinical trials
Reporting of patient-reported outcomes in recent trials in rheumatoid arthritis: a systematic literature review
Quality of life and/or symptom control in randomized clinical trials for patients with advanced cancer
Design and rationale of health-related quality of life and patient-reported outcomes assessment in the Frequent Hemodialysis Network trials
Measuring symptom response to pharmacological interventions in patients with COPD: a review of instruments used in clinical trials
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- Search COMET
- Send general feedback / enquiry
- Register a new project / study
- Report a missing study
- Find out about how to measure
- A walk through core outcome sets
- 3rd Meeting of the COMET Initiative, 20-21 June 2013, Manchester, UK
The COMET (Core Outcome Measures in Effectiveness Trials) Initiative will hold its third meeting in Manchester on 20th to 21st June 2013.