Core Outcome Measures in Effectiveness Trials

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The COMET (Core Outcome Measures in Effectiveness Trials) Initiative brings together people interested in the development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’. These sets represent the minimum that should be measured and reported in all clinical trials of a specific condition, and are also suitable for use in clinical audit or research other than randomised trials. The existence or use of a core outcome set does not imply that outcomes in a particular trial should be restricted to those in the relevant core outcome set. Rather, there is an expectation that the core outcomes will be collected and reported, making it easier for the results of trials to be compared, contrasted and combined as appropriate; while researchers continue to explore other outcomes as well. COMET aims to collate and stimulate relevant resources, both applied and methodological, to facilitate exchange of ideas and information, and to foster methodological research in this area.

When searching the COMET database, please note that a systematic review is currently underway to identify eligible material, and we are continually updating the database as we identify eligible studies. Therefore, the records retrieved by any search might increase on a daily basis.

The COMET database currently contains 607 references of planned, ongoing and completed work.

The keyword used for the search will be compared with study title, abstract and author's surname.

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Core resource pack

Useful references for core outcome set developers.

This includes an overview of the problems with outcomes in trials, key issues to consider in the development of a core outcome set, examples of core outcome set development, and things to think about once a COS is agreed. To read more, click here.

Latest News

  • Monday 30 March, 2015 - COMET Initiative and EURORDIS Webinar

    COMET Initiative and EURORDIS Webinar on the Role of Patient Advocates in harmonising outcome sets in clinical research. Watch the webinar here.


    It is our great pleasure to announce that the deadline for abstract submission for COMET V has been extended to 27th March 2015.

    Final acceptance will be notified to the main author by email no later than 2nd April 2015.

    To find out more and submit an abstract please visit

  • Thursday 29 January, 2015 - A core set of trial outcomes for every medical discipline?

    An important step towards truly meaningful “big data”

    An editorial by Walter Koroshetz, acting director

    Electronic data sharing infrastructure is now more accessible, the concept of “big data”
    has become popular. The investigator community can advance its science to another level by embracing the culture change and ensure that big data are good data. Establishing and using
    common outcome measures is the first step. Read the full editorial here.

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