Core Outcome Measures in Effectiveness Trials

The COMET (Core Outcome Measures in Effectiveness Trials) Initiative brings together people interested in the development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’. These sets represent the minimum that should be measured and reported in all clinical trials of a specific condition, and are also suitable for use in clinical audit or research other than randomised trials. The existence or use of a core outcome set does not imply that outcomes in a particular trial should be restricted to those in the relevant core outcome set. Rather, there is an expectation that the core outcomes will be collected and reported, making it easier for the results of trials to be compared, contrasted and combined as appropriate; while researchers continue to explore other outcomes as well. COMET aims to collate and stimulate relevant resources, both applied and methodological, to facilitate exchange of ideas and information, and to foster methodological research in this area.

When searching the COMET database, please note that a systematic review is currently underway to identify eligible material, and we are continually updating the database as we identify eligible studies. Therefore, the records retrieved by any search might increase on a daily basis.

The COMET database currently contains 706 references of planned, ongoing and completed work.

The keyword used for the search will be compared with study title, abstract and author's surname.

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To view a demonstration of how to search the COMET database click here

Core resource pack

Useful references for core outcome set developers.

This includes an overview of the problems with outcomes in trials, key issues to consider in the development of a core outcome set, examples of core outcome set development, and things to think about once a COS is agreed. To read more, click here.

Latest News

  • Friday 13 November, 2015 - The COMET initiative database: progress and activities update (2014)

    The COMET Initiative database is a repository of studies relevant to the development of core outcome sets (COS). Use of the website continues to increase, with more than 16,500 visits in 2014 (36 % increase over 2013), 12,257 unique visitors (47 % increase), 9780 new visitors (43 % increase) and a rise in the proportion of visits from outside the UK (8565 visits; 51 % of all visits). By December 2014, a total of 6588 searches had been completed, with 2383 in 2014 alone (11 % increase). The growing awareness of the need for COS is reflected in the website and database usage figures. Read the full report here.

  • Monday 12 October, 2015 - Social network analysis identified central outcomes for core outcome sets using systematic reviews of HIV/AIDS

    A group of researchers applied social network analysis methods to understand outcome co-occurrence patterns in HIV/AIDS systematic reviews, and identify outcomes central to the network of outcomes in HIV/AIDS. Read the full article here.

  • Monday 24 August, 2015 - COS-STAR: a reporting guideline for studies developing core outcome sets (protocol)

    Core outcome sets can increase the efficiency and value of research and, as a result, there are an increasing number of studies looking to develop core outcome sets (COS). However, the credibility of a COS depends on both the use of sound methodology in its development and clear and transparent reporting of the processes adopted. To date there is no reporting guideline for reporting COS studies. The aim of this programme of research is to develop a reporting guideline for studies developing COS and to highlight some of the important methodological considerations in the process. Read the full protocol here.

Recently Added Studies

  • Outcomes mapping study for childhood vaccination communication: too few concepts were measured in too many ways

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  • Defining core outcome set in adults with eosinophilic esophagitis

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  • Title: A review of outcomes presented in published and unpublished studies of pediatric acute lymphoblastic leukemia: Toward the development of a core outcome set.

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  • Developing and testing a Core Outcome Set for Burn Injury in Children and Young Adults

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  • A review of outcomes presented in studies of shoulder arthroplasty: Toward the development of a core outcome set

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