Core Outcome Measures in Effectiveness Trials

The COMET (Core Outcome Measures in Effectiveness Trials) Initiative brings together people interested in the development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’. These sets represent the minimum that should be measured and reported in all clinical trials of a specific condition, and are also suitable for use in clinical audit or research other than randomised trials. The existence or use of a core outcome set does not imply that outcomes in a particular trial should be restricted to those in the relevant core outcome set. Rather, there is an expectation that the core outcomes will be collected and reported, making it easier for the results of trials to be compared, contrasted and combined as appropriate; while researchers continue to explore other outcomes as well. COMET aims to collate and stimulate relevant resources, both applied and methodological, to facilitate exchange of ideas and information, and to foster methodological research in this area.

When searching the COMET database, please note that a systematic review is currently underway to identify eligible material, and we are continually updating the database as we identify eligible studies. Therefore, the records retrieved by any search might increase on a daily basis.


The COMET database currently contains 501 references of planned, ongoing and completed work.

The keyword used for the search will be compared with study title, abstract and author's surname.

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BMJ Blogs


We maintain a BMJ blog about COMET activities and outputs. Our most recent blog is shown below:

Naohiro Yonemoto: Japan welcomes new international research collaboration
by BMJ Group
Friday 14 June, 2013

View all COMET BMJ blogs

Latest News

  • Monday 03 February, 2014 - Raising awareness of the work of the COMET Initiative amongst patients and patient involvement groups

    COMET recognises the expertise and crucial contribution of patients and carers in developing relevant core outcome sets.  It is therefore important to ensure that organisations promoting patient and public involvement in research and those that provide information to patients about clinical trials are aware of the work of COMET.  In recent weeks COMET has been linked with two key organisations, INVOLVE and ECRAN.

    INVOLVE is a national advisory group that supports greater public involvement in England through National Health Service, public health and social care research (www.invo.org.uk).  It shares knowledge and learning on public involvement in research.  INVOLVE have recently established an online resource called invoDIRECT on its main website.  This resource provides a searchable map identifying groups and organisations that support patient and public involvement in research.  COMET is now listed on this resource: www.invo.org.uk/find-out-more/invodirect.

    The European Communication on Research Awareness Needs (ECRAN) project aims to make understanding clinical trials - a relevant element of medical research - easy, and tells patients all about taking part in them.  On their website they list key projects of relevance to patients.  COMET is now listed on their website (which will soon be available in 6 languages): http://ecranproject.eu/en/content/educational-materials-faqs-glossaries.

  • Thursday 19 December, 2013 - Involving patient research partners has a significant impact on outcomes research: a responsive evaluation of the international OMERACT conferences

    Including patients as partners in OMERACT conferences has widened its focus and adjusted the way of working. It has resulted in new developments in the research agenda and the use of more patient-relevant outcomes in clinical trials. These collaborations have influenced perceptions and beliefs among many patients and researchers, and led to wider patient involvement as partners in research. Read the full paper here.

  • Thursday 07 November, 2013 - Relevant funding opportunity for a UK-based clinician

    The British Medical Association, through its Board of Science, is offering the Strutt and Harper grant (£55,000) to assist research into improving the development or implementation of clinical outcome measures, including qualitative measures. Applicants must be registered medical practitioners in the UK and members of the BMA (grant holders are required to hold BMA membership for the duration of the grant). Applications for the above grant should be for proposed or current work on a specific project relating to improving the development or implementation of clinical outcome measures. The closing date for receipt of completed applications is Friday 14 March 2014. For more information, please visit http://bma.org.uk/developing-your-career/portfolio-career/research-grants/research-grants-details/research-grants-strutt-harper

Recently Added Studies

  • Development of core outcome sets for interventions to improve informed consent for clinical trials

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  • Better reporting and greater homogeneity in outcome measures are seen in randomized trial protocols when guidelines exist

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  • Heterogeneity in outcomes meta-analyzed among systematic reviews in renoprotective field: an observational review

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  • Recommendations for the use of common outcome measures in pediatric traumatic brain injury research

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  • Salutogenically focused outcomes in systematic reviews of intrapartum interventions: A systematic review of systematic reviews

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