Defining a core outcome set in Non-Hodgkin lymphoma for future clinical trials

The HARMONY Alliance is a public-private European Network established in 2017, which currently includes 53 partners and 37 associated members from 22 countries. One of the objectives of HARMONY is improving the understanding and treatment of hematological malignancies by using Big Data.
One of the work packages within HARMONY (work package 2; WP 2) is focused on defining outcomes that are relevant to each hematological malignancies considered in HARMONY.
This study aims to define a core outcome set (COS) for Non-Hodgkin lymphoma (NHL). Different stakeholders will provide their expert feedback in a Delphi survey and rank different outcomes according to their importance. The different stakeholder groups include clinicians, patients and patient advocates and members of EFPIA (European Federation of Pharmaceutical Industries and Associations).
A future use of COS can improve the comparability of clinical trials and the consistency of reporting. Therefore COS can help to ensure appropriate outcomes are measured in future clinical trials.

Contributors

Lars Bullinger, WP 2 Leader, HARMONY Partner Charit? Berlin
Renate Schulze-Rath, WP 2 Leader, HARMONY Partner Bayer
HARMONY Alliance, Healthcare Alliance for Resourceful Medicine Offensive against Neoplasms in Hematology
Katharina Lang

Further Study Information

Current Stage: Ongoing
Date: March 2020 - November 2020
Funding source(s): Innovative Medicine Initiative (IMI) 2 Joint grant agreement No. 116026


Health Area

Disease Category: Blood disorders, Cancer

Disease Name: Non-Hodgkin's lymphoma (NHL)

Target Population

Age Range: 18 - 100

Sex: Either

Nature of Intervention:

Stakeholders Involved

- Clinical experts
- Consumers (patients)
- Patient/ support group representatives
- Pharmaceutical industry representatives
- Regulatory agency representatives
- Researchers

Study Type

- COS for clinical trials or clinical research
- COS for practice

Method(s)

- Consensus meeting
- Delphi process

Multi-round Delphi process, final consensus meeting

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