Core Outcome Measures in Effectiveness Trials

Variation in the reporting of outcomes among pregnant women with epilepsy: a systematic review

General Information

Abstract:
Studies on pregnant women with epilepsy should evaluate both neurological and pregnancy outcomes. We undertook a systematic review of the literature of studies on pregnant women with epilepsy to collate the outcomes reported, and the quality of outcomes report in these studies. We searched major electronic databases (from 1999 until January 2015). Two independent reviewers selected studies and extracted data on study design, the risk of bias of the studies, journal impact factor and the quality of reported outcomes. We assessed the quality outcomes report using a six items standardised tool (score range 0-6). There were 70 different outcomes reported in 232 studies (maternal neurological (13/70, 19%), fetal and neonatal (28/70, 40%), and obstetric outcomes (29/70, 41%)). Most studies reported on major congenital fetal abnormalities (103/232, 44%), followed by live birth (60/232, 26%). Quality of the reported outcomes was poor (mean 1.54, SD 1.36). It was associated with journal impact factor (p=0.007), but not with study design (p=0.60), or risk of bias (p=0.17). The outcomes reported in studies on pregnant women with epilepsy varied widely, and the quality of the outcomes report was poor. There is a need to identify a set of core outcome to harmonise reporting in future clinical studies.

Authors:
Al Wattar, B. H. Placzek, A. Troko, J. Pirie, A. M. Khan, K. S. McCorry, D. Zamora, J. Thangaratinam, S. Empire Collaborative Network

Publication

Journal:
Eur J Obstet Gynecol Reprod Biol
Volume:
195
Issue:
Pages:
193 - 9
Year:
2015
DOI:
Further Study Information

Date:
Funding source(s):

Health Area

Disease Category
Pregnancy & childbirth

Disease Name
Epilepsy
Epilepsy in pregnancy

Target Population

Age Range
-

Sex
Unknown


Nature / type of Intervention
Unknown

Method(s)

Unknown

Stakeholders Involved

Unknown

Study Type

Systematic review of outcomes measured in trials

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