Core Outcome Measures in Effectiveness Trials

New insights into the burden and costs of multiple sclerosis in Europe

General Information

Abstract:
BACKGROUND: The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care. OBJECTIVES: This European burden of illness study provides data that can be combined with other evidence to assess whether management approaches provide value to society. METHODS: A cross-sectional study was conducted in 16 countries. Patients reported on their disease, health-related quality of life (HRQoL) and resource consumption. Descriptive analyses were performed by disease severity. Costs are reported from a societal perspective in 2015euro PPP (adjusted for purchasing power parity). RESULTS: The 16,808 participants had a mean age of 51.5 years, and 52% had relapsing-remitting multiple sclerosis (RRMS). Work capacity declined from 82% to 8%, and utility declined from normal population values to less than zero with advancing disease. Mean costs were 22,800euro PPP in mild, 37,100euro PPP in moderate and 57,500euro PPP in severe disease; healthcare accounted for 68%, 47% and 26%, respectively. Fatigue and cognitive difficulties were reported by 95% and 71% of participants, respectively; both had a significant independent effect on utility. CONCLUSION: Costs and utility were highly correlated with disease severity, but resource consumption was heavily influenced by healthcare systems organisation and availability of services.

Authors:
Kobelt, G. Thompson, A. Berg, J. Gannedahl, M. Eriksson, J. Mscoi Study Group European Multiple Sclerosis, Platform

Publication

Journal:
Mult Scler
Volume:
23
Issue:
8
Pages:
1123 - 1136
Year:
2017
DOI:
Further Study Information

Date:
Funding source(s):

Health Area

Disease Category
Neurology

Disease Name
Multiple sclerosis (MS)

Target Population

Age Range
-

Sex
Unknown


Nature / type of Intervention
Unknown

Method(s)

Survey

Stakeholders Involved

Consumers (patients)

Study Type

Patient perspectives

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