The development of a core outcome set for interventions in the treatment of uncomplicated urinary tract infections (UTI’s) in adult patients.

In order to address the inappropriate use of antimicrobials in the treatment of uncomplicated UTIs in primary care, further research needs to be undertaken in this area. However, inconsistency in the choice of outcomes reported have resulted in substantial challenges in synthesising evidence, ultimately limiting the capability to influence practice and policy.

The development of a core outcome set (COS), as a minimum set of agreed standardised outcomes to be reported in all trials, will address this problem. The development of a COS for interventions in the treatment of uncomplicated UTIs in adult patients would minimise the heterogeneity of outcome measures, allowing the efficient comparison and synthesis of trials in addition to encouraging a more complete reporting of outcomes which ultimately limits reporting bias.

Protocol: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3194-x

Contributors

Professor Declan Devane
Dr. Sinead Duane
Dr. Akke Vellinga
Dr. Marie Tierney
Dr. Sandra Galvin
Professor Andrew Murphy
Professor Martin Cormican
Dr. Andrew Smyth

Further Study Information

Current Stage: Ongoing
Date: February 2017 - March 2021
Funding source(s): Health Research Board (Ireland)


Health Area

Disease Category: Urology

Disease Name: Urinary Tract Infection

Target Population

Age Range: 18 - 100

Sex: Female

Nature of Intervention: Any

Stakeholders Involved

- Clinical experts
- Researchers

Study Type

- COS for clinical trials or clinical research

Method(s)

- Consensus meeting
- Delphi process
- Systematic review

A three step approach will be used to concurrently develop the COS.
1. A systematic review to identify primary outcomes previously reported in clinical trials evaluating the interventions in the treatment of UTI’s;
2. Refinement of outcomes by an iterative process using a Delphi study.
3. A consensus development meeting with stakeholders will be held and the COS agreed upon prior to disseminating to stakeholders.

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