Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy following twelve months or more of regular unprotected sexual intercourse. Randomised trials evaluating treatments for subfertility have reported many different outcomes and outcome measures. Such variation contributes to an inability to compare and combine individual trials, limiting the usefulness of evidence synthesis to inform clinical practice.

COMMIT-MaleInferility seeks to develop a core outcome set for male infertility trials and form part of the wider COMMIT project.


Michael Rimmer
James M N Duffy
Ruth Howie

Further Study Information

Current Stage: Ongoing
Date: June 2020 - 2024
Funding source(s): To be confirmed

Health Area

Disease Category: Pregnancy & childbirth

Disease Name: Male infertility

Target Population

Age Range: 15 - 55

Sex: Male

Nature of Intervention: Any

Stakeholders Involved

- Charities
- Clinical experts
- Conference participants
- Consumers (patients)
- Epidemiologists
- Governmental agencies
- Journal editors
- Methodologists
- Patient/ support group representatives
- Pharmaceutical industry representatives
- Policy makers
- Regulatory agency representatives
- Researchers
- Service commissioners
- Service providers
- Service users
- Statisticians

Study Type

- COS for clinical trials or clinical research


- Consensus meeting
- Delphi process
- Literature review