Outcome measures in childhood glaucoma: a systematic review of randomized controlled trials

To synthesize the outcome measures used by randomized controlled trials (RCTs) for childhood glaucoma.

MEDLINE, EMBASE, and Scopus were searched from inception to February 17, 2023. Randomized controlled trials and observational studies related to childhood glaucoma were included. Primary and secondary outcomes were extracted and the data was used to generate a literature review.

This review identified 42 unique reports pertaining to childhood glaucomas. Most of the studies originated from Egypt, India, and the USA. Intraocular pressure (IOP) outcomes were the most frequent outcomes studied, followed by clinical outcomes and safety outcomes. Clinical outcomes were the most common secondary outcomes studied, followed by IOP outcomes and safety outcomes.

This systematic review found heterogenous outcomes with IOP outcomes as the most studied primary outcome. As the remaining outcomes were not consistently utilized, this review highlights the need for a consensus on studies of pediatric glaucoma.


Gurkaran S. Sarohia, Maram E. A. Abdalla Elsayed, Carlos Eduardo Solarte, Stella J. Hornby, John Brookes, Ta Chen Peter Chang, Rizwan Malik


Journal: Graefe's Archive for Clinical and Experimental Ophthalmology
Pages: -
Year: 2023
DOI: 10.1007/s00417-023-06061-w

Further Study Information

Current Stage: Completed
Funding source(s):

Health Area

Disease Category: Child health, Eyes & vision

Disease Name: Glaucoma , Childhood glaucoma

Target Population

Age Range: Unknown

Sex: Either

Nature of Intervention:

Stakeholders Involved

Study Type

- Systematic review of outcomes measured in trials


- Systematic review

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