Core outcome set for pregnancy outcomes in pregnancies complicated by cancer (COSPOP)

Cancer complicating pregnancy is a rare coexistence. Approximately 1/1000 pregnancies is complicated by any form of malignancy. Incidence of cancer in pregnancy is similar to that of non-pregnant women with the same age. Diagnostic and therapeutic management are more complex as two people are involved. Several collaborative (international) research projects are undertaken to try to optimize diagnostic and therapeutic management in pregnant women who also have cancer.

Trials studying outcomes of mother and fetus in case of malignancy in pregnancy reported different outcomes, resulting in inability to compare studies. It is time to align the outcomes to facilitate the already existing fruitful collaborations t in malignancy and pregnancy studies.

Objective: we aim to develop a core outcome set for pregnancy-related outcomes for pregnancies complicated by malignancy, irrespective of type of malignancy.

Contributors

dr. S.J. Gordijn, department of Obstetrics, University Medical Center Groningen (UMCG), The Netherlands,
drs. V. Wolters, department of Gynecologic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
dr. J.W. Ganzevoort, department of Obstetrics, Amsterdam Medical Center (AMC), Amsterdam, The Netherlands.
prof. dr. F. Amant, head CGAO, Antoni van Leeuwenhoek-Netherlands Cancer institue, Amsterdam Medical Center (AMC), The Netherlands.

Further Study Information

Current Stage: Ongoing
Date: April 2018 - September 2019
Funding source(s): None


Health Area

Disease Category: Cancer, Pregnancy & childbirth

Disease Name: N/A

Target Population

Age Range: 18 - 48

Sex: Female

Nature of Intervention: Any

Stakeholders Involved

- Clinical experts
- Consumers (caregivers)
- Consumers (patients)
- Patient/ support group representatives

Study Type

- COS for clinical trials or clinical research
- COS for practice

Method(s)

- Consensus meeting
- Delphi process
- Literature review

We will start with a review of existing outcomes that will inform the Delphi procedure. If necessary and applicable we will organise a consensus meeting as a satellite meeting of a conference.

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