Assessing effectiveness in acne clinical trials: steps towards a core outcome measure set

Background Acne ranks second to dermatitis in terms of global burden of skin disease. As such, it is essential that data on treatment efficacy are generated in a way that maximizes the opportunity for comparison among treatments. Interest in developing core outcome sets for use in clinical trials to standardize data collection in skin disease is surging.

Objectives The goal of this review is to provide an update on the efforts underway, challenges encountered and future directions in the development of an acne core outcome measure set for use in clinical trials.

Methods The activities of the Acne Core Outcomes Research Network (ACORN) are presented in the context of currently acceptable methodologies for core outcome set development.

Conclusions Emphasis is placed on following a rigorous methodology, involving patients and recognizing a role for emerging technologies.

Contributors

D.M. Thiboutot, A.M. Layton, M.-M. Chren, E.A. Eady and J. Tan

Publication

Journal: British Journal of Dermatology
Volume: 181
Issue:
Pages: 700 - 706
Year: 2019
DOI: 10.1111/bjd.18011

Further Study Information

Current Stage: Completed
Date:
Funding source(s): ACORN has received funding from the U.S. National Institute of Health, award number 1U01AR065109. International Dermatology Outcome Measures (IDEOM) has also provided financial support for this initiative.


Health Area

Disease Category: Skin

Disease Name: Acne

Target Population

Age Range: 14 - 45

Sex: Either

Nature of Intervention: Any

Stakeholders Involved

Study Type

- Recommendations for outcome measures (measurement/how)

Method(s)