Strategy for standardization of preeclampsia research study design

Preeclampsia remains a major problem worldwide for mothers and babies. Despite intensive study, we have not been able to improve the management or early recognition of preeclampsia. At least part of this is because of failure to standardize the approach to studying this complex syndrome. It is possible that within the syndrome there may be different phenotypes with pathogenic pathways that differ between the subtypes. The capacity to recognize and to exploit different subtypes is of obvious importance for prediction, prevention, and treatment. We present a strategy for research to study preeclampsia, which will allow discrimination of such possible subtypes and also allow comparison and perhaps combinations of findings in different studies by standardized data and biosample collection. To make studies relevant to current clinical practice, the definition of preeclampsia can be that currently used and accepted. However, more importantly, sufficient data should be collected to allow other diagnostic criteria to be used and applied retrospectively. To that end, we present what we consider to be the minimum requirements for a data set in a study of preeclampsia that will facilitate comparisons. We also present a comprehensive or optimal data set for in-depth investigation of pathophysiology. As we approach the definition of phenotypes of preeclampsia by clinical and biochemical criteria, adherence to standardized protocols will hasten our understanding of the causes of preeclampsia and development of targeted treatment strategies.


Myatt, L. Redman, C. W. Staff, A. C. Hansson, S. Wilson, M. L. Laivuori, H. Poston, L. Roberts, J. M.


Journal: Hypertension
Volume: 63
Issue: 6
Pages: 1293 - 1301
Year: 2014
DOI: 10.1161/HYPERTENSIONAHA.113.02664

Further Study Information

Current Stage: Not Applicable
Funding source(s): The Global Pregnancy CoLaboratory is funded by the University of British Columbia, a grantee of the Bill & Melinda Gates Foundation.

Health Area

Disease Category: Heart & circulation, Pregnancy & childbirth

Disease Name: Pre-eclampsia

Target Population

Age Range: Unknown

Sex: Female

Nature of Intervention: Not specified

Stakeholders Involved

- Not Specified

Study Type

- Recommendations made
- Minimum dataset
- COS for clinical trials or clinical research


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