Core Outcome Measures in Effectiveness Trials

A core outcome set for thyroid dysfunction

General Information

Thyroid dysfunction encompassed the spectrum of disorders resulting from under- to over-secretion of thyroid hormones. This global health problem that substantially impacts on well-being and functional ability is modifiable with appropriate treatment.

Currently, there is no published core outcome set for use in interventions for thyroid dysfunction. Heterogenous outcomes measures vary in different clinical research studies limit the ability to combine and utilise data efficiently.

This study aims to develop a core outcome set for the management of thyroid dysfunction in an adult population.

1. Dr Cheow Peng Ooi, Principal Investigator, Endocrinologist/Lecturer in Medicine, Universiti Putra Malaysia
2. Professor Nor Azmi Kamaruddin, Head of Study Steering Committee, Professor of Medicine/Senior Consultant Endocrinologist, National University of Malaysia Medical Centre
3. Professor Norela Sukor, Professor of Medicine/Senior Consultant Endocrinologist, National University of Malaysia Medical Centre
4. Associate Professor Norlaila Mustafa, Senior Consultant Endocrinologist/senior Lecturer in Medicine, National University of Malaysia Medical Centre

Further Study Information

Current Stage:
2019 - 2021
Funding source(s):
Putra University Research Grant and others

Health Area

Disease Category
Endocrine & metabolic

Disease Name
Thyroid dysfunction

Target Population

Age Range
18 - 100


Nature / type of Intervention


Consensus meeting
Delphi process
Systematic review

A systematic review will be carried out to determine the outcome measures and contextual factors in reported in the spectrum of thyroid dysfunctions ranging from hyperthyroidism to hypothyroidism. A semi-structured discussion meeting will inform the Delphi survey development and the survey will comprise of two rounds. A consensus meeting will be held with key stakeholders to discuss the identified outcomes and refine suitable measures to assess them.

Stakeholders Involved

Clinical experts
Consumers (patients)

Study Type

COS for clinical trials or clinical research
COS for practice
Recommendations for outcome measures (measurement/how)

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