Thyroid dysfunction encompassed the spectrum of disorders resulting from under- to over-secretion of thyroid hormones. This global health problem that substantially impacts on well-being and functional ability is modifiable with appropriate treatment.
Currently, there is no published core outcome set for use in interventions for thyroid dysfunction. Heterogenous outcomes measures vary in different clinical research studies limit the ability to combine and utilise data efficiently.
This study aims to develop a core outcome set for the management of thyroid dysfunction in an adult population.
Project Leader
CheowPeng Ooi, Endocrinology/Internal Medicine, International Medical University, Malaysia
Researchers
Professor Dr Norlela Sukor, Senior Endocrinology Consultant, Professor of Medicine, National University of Malaysia
Professor Dato Dr Lokman Hakim bin Sulaiman, Senior Epidemiology Consultant, Professor of Public Health, International Medical University, Malaysia
Dr Saiful Safuan Mohd Sani, Senior Consultant Physician, Institute of Clinical Research, Ministry of Health, Malaysia
Professor Paula Williamson, Professor of Medical Statistics and Health Data Science, COMET (Core Outcome Measures in Effectiveness Trials) Initiative lead, University of Liverpool, United Kingdom
Disease Category: Endocrine & metabolic
Disease Name: Thyroid dysfunction
Age Range: 18 - 100
Sex: Either
Nature of Intervention: Any
- Clinical experts
- Consumers (patients)
- Researchers
- COS for clinical trials or clinical research
- COS for practice
- Recommendations for outcome measures (measurement/how)
- Consensus meeting
- Delphi process
- Interview
- Survey
- Systematic review
A systematic review will be carried out to determine the outcome measures and contextual factors in reported in the spectrum of thyroid dysfunctions ranging from hyperthyroidism to hypothyroidism. A semi-structured discussion meeting will inform the Delphi survey development and the survey will comprise of two rounds. A consensus meeting will be held with key stakeholders to discuss the identified outcomes and refine suitable measures to assess them.