Core Outcome Measures in Effectiveness Trials

Developing a Core Outcome Set in Surgery for Cauda Equina Syndrome

General Information

Summary:
Cauda Equina Syndrome is a condition where compression of the lumbosacral nerve roots causes severe disability in terms of bladder, bowel, sexual function and sensory motor deficits in lower limbs. Studies have been done looking at optimum timing of intervention and short term outcomes but little consideration on long term outcomes. There is heterogeneity in the number of outcomes and way it is measured. We propose the development of a core outcome set to also address the outcomes for patients who have undergone decompressive surgery for cauda equina syndrome secondary to lumbar disc herniation.

Contributors:
Mr Nisaharan Srikandarajah/ University of Liverpool (Principal Investigator)
Mr Martin Wilby/ The Walton Centre NHS Foundation Trust (co-supervisor)
Mr Simon Clark/ The Walton Centre NHS Foundation Trust (co-supervisor)
Professor Anthony Marson/ University of Liverpool (Main supervisor)
Professor Paula Williamson/ University of Liverpool (co-supervisor)
Dr Adam Noble/ University of Liverpool (co-supervisor)

Further Study Information

Current Stage:
Ongoing
Date:
February 2016 - January 2019
Funding source(s):
Medtronic Industry via The Walton Centre NHS Research funds, Royal College of Surgeons (Eng) Fellowship Award

Health Area

Disease Category
Neurology
Orthopaedics & trauma

Disease Name
Cauda equina syndrome

Target Population

Age Range
18 - 65

Sex
Either


Nature / type of Intervention
Surgery

Method(s)

Consensus meeting
Delphi process
Interview
Systematic review

Systematic review of current literature regarding outcomes for patients post lumbar decompression for cauda equine syndrome. Qualitative interviews of 20-30 patients to develop a long list of outcomes. Two rounds of Delphi process with key stakeholders to prioritise the long list. A consensus meeting with key stakeholders to decide on the core outcome set.


Stakeholders Involved

Clinical experts
Consumers (caregivers)
Consumers (patients)
Patient/ support group representatives

Study Type

COS for clinical trials or clinical research

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