Background
Standardisation of outcomes measured and reported in trials of infant-feeding interventions to prevent childhood obesity is essential to evaluate and synthesise intervention effects. The aim of this study is to develop an infant-feeding core outcome set for use in randomised trials of infant-feeding interventions, with children 1 year old or under, to prevent childhood obesity.
Methods
Core outcome set development followed four stages: (1) systematic review of outcomes reported in the extant literature; (2) meeting with national and international stakeholders to discuss and clarify identified outcomes; (3) e-Delphi study with national and international stakeholders to prioritise outcomes; (4) meeting with national and international stakeholders to reach consensus on outcomes. Stakeholders in stages 2–4 were paediatricians, general practitioners, nurses, midwives, non-clinician researchers, parents, dieticians, nutritionists, and childcare providers.
Results
Twenty-six outcomes were identified for inclusion in the core outcome set. These were grouped in nine outcome domains: ‘breastfeeding and formula feeding’, ‘introduction of solids’, ‘parent feeding practices and styles’, ‘parent knowledge and beliefs’, ‘practical feeding’, ‘food environment’, ‘dietary intake’, ‘perceptions of infant behaviour and preferences’, and ‘child weight’.
Conclusions
The core outcome set identified in this study is the minimum that should be measured and reported in trials of infant-feeding interventions to prevent childhood obesity. This standardisation of outcomes will enable more comprehensive examination and synthesis of the effects of infant-feeding interventions to prevent childhood obesity.
Karen Matvienko-Sikar, Ciara Griffin, Colette Kelly, Caroline Heary, Majken Lillholm Pico Pedersen, Niamh McGrath, Elaine Toomey, Janas Harrington, Marita Hennessy, Michelle Queally, Catherine Hayes, Jenny McSharry, Declan Devane, Molly Byrne & Patricia M. Kearney
Disease Category: Child health
Disease Name: Feeding the infant, Obesity
Age Range: 0 - 1
Sex: Either
Nature of Intervention: Diet and nutrition
- Clinical experts
- Consumers (caregivers)
- Families
- Researchers
- Service providers
- Service users
- COS for clinical trials or clinical research
- Consensus meeting
- Delphi process
- Semi structured discussion
- Systematic review
Core outcome set development followed four stages: (1) systematic review of outcomes reported in the extant
literature; (2) meeting with national and international stakeholders to discuss and clarify identified outcomes; (3) e-Delphi study with national and international stakeholders to prioritise outcomes; (4) meeting with national and international stakeholders to reach consensus on outcomes. Stakeholders in stages 2–4 were paediatricians, general practitioners, nurses, midwives, non-clinician researchers, parents, dieticians, nutritionists, and childcare providers.