Development of a core outcome set for diagnostic and therapeutic studies of urinary tract infection in pregnancy

Urinary tract infection (UTI) in pregnancy is a common problem and has been associated with preterm birth and pyelonephritis. However, there is a concern that tests and treatment for UTI are not appropriately targeted, leading to both underuse and overuse of antibiotics. Antimicrobial resistance is a significant global concern and antibiotic use should be targeted to those who need it. This is difficult to assess, since many studies of UTI in pregnancy do not include outcome measures relevant to pregnancy and there is a lack of standardised approach.
We propose a three-stage process:
(1) systematic review of outcome measures in diagnostic and therapeutic studies of UTI in pregnancy
(2) Delphi process
(3) Consensus development of core outcome set for studies on UTI in pregnancy

Contributors

Dr Jane Currie (PI)
Professor Anna David (supervisor)
Professor James Malone-Lee (supervisor)
Dr Raj Khasriya
Dr Natasha Liou

Further Study Information

Current Stage: Ongoing
Date: September 2020 - September 2021
Funding source(s): No funding sources


Health Area

Disease Category: Pregnancy & childbirth

Disease Name: Urinary Tract Infection

Target Population

Age Range: 13 - 60

Sex: Female

Nature of Intervention: Any

Stakeholders Involved

- Charities
- Clinical experts
- Consumers (patients)
- Patient/ support group representatives
- Researchers

Study Type

- COS for clinical trials or clinical research
- COS for practice

Method(s)

- Consensus meeting
- Delphi process
- Literature review
- Systematic review

(1) systematic review of outcome measures in diagnostic and therapeutic studies of UTI in pregnancy
(2) Delphi process
(3) Consensus development of core outcome set for studies on UTI in pregnancy

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