COMET Initiative | Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017. [Review]

Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017. [Review]

Objective: To assess the uptake of the OMERACT-OARSI (Outcome Measures in Rheumatology- Osteoarthritis Research Society International) core outcome set (COS) domains in hip and/or knee osteoarthritis (OA) trials.

Methods: There were 382 trials of hip and/or knee OA identified from the ClinicalTrial.gov registry from 1997 to 2017. Frequency of COS adoption was assessed by year and per 5-yearly phases.

Results: COS adoption decreased from 61% between 1997 and 2001 to 38% between 2012 and 2016. Pain (95%) and physical function (86%) were most consistently adopted. Patient’s global assessment (48%) was the principal missing domain.

Conclusion: Limited adoption of the COS domains indicates that further consideration to improve uptake is required.

Aim

To assess the uptake of the OMERACT-OARSI (Outcome Measures in Rheumatology- Osteoarthritis Research Society International) core outcome set (COS) domains in hip and/or knee osteoarthritis (OA) trials.

Contributors

Toby O Smith 1 2, Michael Mansfield 1 2, Gillian A Hawker 1 2, David J Hunter 1 2, Lyn M March 1 2, Maarten Boers 1 2, Beverley J Shea 1 2, Robin Christensen 1 2, Francis Guillemin 1 2, Caroline B Terwee 1 2, Paula R Williamson 1 2, Ewa M Roos 1 2, Richard F Loeser 1 2, Thomas J Schnitzer 1 2, Margreet Kloppenburg 1 2, Tuhina Neogi 1 2, Christoph H Ladel 1 2, Gurdyal Kalsi 1 2, Ulrike Kaiser 1 2, Thomas W Buttel 1 2, Anne E Ashford 1 2, Ali Mobasheri 1 2, Nigel K Arden 1 2, Alan Tennant 1 2, Marc C Hochberg 1 2, Maarten de Wit 1 2, Peter Tugwell 1 2, Philip G Conaghan 3 4

Publication

Journal: Journal of Rheumatology
Volume: 46
Issue: 8
Pages: 976 - 980
Year: 2019
DOI: 10.3899/jrheum.181066

Further Study Information

Current Stage: Completed
Date:
Funding source(s): Dr Toby Smith was awarded an Arthritis Action grant and a EULAR OMERACT Educational Bursary. TS is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre, Oxford and PGC is supported, in part, by the NIHR Leeds Biomedical Research Centre.

Health Area

Disease Category: Rheumatology

Disease Name: Osteoarthritis

Target Population

Age Range: Unknown

Sex: Either

Nature of Intervention: Any

Stakeholders Involved

Study Type

- COS methods research
- COS uptake study

Method(s)

- Systematic review
- Trial registry

We searched the trials registry ClinicalTrials.gov on 6th July 2017 to identify all phase 3 or 4, drug or non-drug trials registered from January 1997 to July 2017, recruiting people with hip or knee OA. We extracted data on all planned trial outcomes and assessed whether the full OMERACT-OARSI hip and knee OA COS was adopted.