Systematic review of outcome reporting in studies of SCD and pregnancy: marked heterogeneity hinders meaningful data synthesis

No abstract


To comprehensively document all outcomes and definitions reported in studies addressing SCD in pregnancy and the puerperium.


Eran Ashwal, Nadine Shehata, Kevin H. M. Kuo, Michelle Jiyon Ryu, Richard Ward, and Ann Kinga Malinowski


Journal: Blood Advances
Volume: 7
Issue: 10
Pages: -
Year: 2023
DOI: 10.1182/bloodadvances.2022007089

Further Study Information

Current Stage: Completed
Funding source(s):

Health Area

Disease Category: Blood disorders, Pregnancy & childbirth

Disease Name: Sickle Cell Disease

Target Population

Age Range: 16 - 55

Sex: Female

Nature of Intervention: Any

Stakeholders Involved

Study Type

- Systematic review of outcomes measured in trials


- Systematic review

The search strategy was developed and conducted by an information
specialist and structured according to the Peer Review of Electronic Search Strategies 2015 guidelines, including publications in English from January 1998 to September 2019. The review was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria consisted of publications, with maternal, pregnancy-related, or neonatal outcomes in patients with SCD during pregnancy or the puerperium. Two reviewers (A.K.M. and E.A.) independently screened titles and abstracts, reviewed full texts, and abstracted data of included articles.

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