COMET Initiative | Development of a Core Outcome Set for Adult Sepsis

Development of a Core Outcome Set for Adult Sepsis

Despite advances in rapid recognition and resuscitation, sepsis remains a major cause of morbidity and mortality worldwide, underscoring the need for continued research, education, and knowledge translation activities. There is heterogeneity in the outcomes measured and reported in trials evaluating treatments of adult sepsis. In this project, we will develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for adult sepsis. The study will be conducted in four stages: (1)systematic review, (2) Delphi survey (3)consensus meetings and (4)dissemination and implementation strategy.

Contributors

Xinyi Xu (Principal Investigator)
Tianjin University of Traditional Chinese Medicine, Tianjin, China
Lu Xiao (Supervisor)
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China

Further Study Information

Current Stage: Ongoing
Date: August 2023 - 2024
Funding source(s): Tianjin Graduate Research Innovation Project (2022BKY190); TUTCM Graduate Research Innovation Project (YJSKC-20222001);Funding for Development of Academic Subject in the Emergency Department of First Teaching Hospital of Tianjin University of Traditional Chinese Medicine(No.16014)

Health Area

Disease Category: Infectious disease

Disease Name: Sepsis

Target Population

Age Range: 18 - 80

Sex: Either

Nature of Intervention: Drug

Stakeholders Involved

- Clinical experts
- Governmental agencies
- Methodologists
- Patient/ support group representatives
- Policy makers
- Researchers

Study Type

- COS for clinical trials or clinical research
- COS for practice

Method(s)

- Consensus meeting
- Delphi process
- Interview
- Literature review
- Systematic review

The study will be conducted in four stages: (1) systematic review, (2) Delphi survey (3) consensus meetings and (4) dissemination and implementation strategy.

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