Aims
Describe the outcomes reported in research on health systems interventions for type 1 diabetes management in comparison to the outcomes proposed by a core outcome set (COS) for this condition, an essential list of outcomes that studies should measure.
Methods
Systematic search of studies published between 2010 and 2021 reporting health systems interventions directed to improve the management of type 1 diabetes using PubMed, EMBASE and CENTRAL. Information on the outcomes was extracted and classified according to a COS: self-management, level of clinical engagement, perceived control over diabetes, diabetes-related quality of life, diabetes burden, diabetes ketoacidosis, severe hypoglycemia, and glycated hemoglobin (HbA1C).
Results
187 studies were included. Most of the studies included either children (n?=?82/187) or adults (n?=?82/187) living with type 1 diabetes. The most common outcome measured was HbA1C (n?=?149/187), followed by self-management (n?=?105/187). While the least measured ones were diabetes ketoacidosis (n?=?15/187), and clinical engagement (n?=?0/187). None of the studies measured all the outcomes recommended in the COS. Additionally, different tools were found to be used in measuring the same outcome.
Conclusions
This study provides a description of what researchers are measuring when assessing health systems interventions to improve type 1 diabetes management. In contrast to a COS, it was found that there is a predominance of clinical-based outcomes over patient-reported outcome measures.
Describe the outcomes reported in research on health systems interventions for type 1 diabetes management in comparison to the outcomes proposed by a core outcome set (COS) for this condition, an essential list of outcomes that studies should measure.
Jessica Hanae Zafra-Tanaka, Adela del Valle, Antonio Bernabé-Ortiz, J. Jaime Miranda, David Beran
Disease Category: Endocrine & metabolic
Disease Name: Type 1 Diabetes
Age Range: Unknown
Sex: Either
Nature of Intervention: Any
- Systematic review of outcomes measured in trials
- COS uptake study
- Systematic review
A previous search conducted in December 2020 for Pub-Med and Embase was updated,3and a new search for CENTRAL was carried out. We decided to search from 2010 to 2020 to include recently developed and tested health system interventions for type 1 diabetes management. The last search was done in January 2022 and included all articles published up to 31st December 2021. See Annex for the search strategies used in this study.