Moving beyond pain intensity as the primary outcome measure: the INTEGRATE pain framework and beyond

In clinical trials as well as routine clinical care, pain intensity is currently the primary research outcome that is used to identify the impact of pain management treatments. However, assessment of this domain alone hinders the understanding of the impact of pain and pain-related symptoms for patients. To advance the management of pain, we need to (1) measure bio-psycho-social outcomes that are important to all stakeholders, including to those with lived pain experience, (2) ensure harmonization of outcome assessment by implementing core outcome sets, (3) use assessment tools that have been validated and have content validity, (4) use the same questionnaires in both research and clinical practice so that research informs clinical practice and vice versa, and (5) consider tailoring questionnaires to the person with lived pain experience, eg, by moving toward an idiographic approach. The pain management field is moving toward a personalized approach to care and the use of harmonized/standardized patient-reported outcomes, and patient-reported outcome measures can help advance the pain management field and make care more patient-centered.

Contributors

Giulia Bova, Annick L De Paepe, Kate M Nicholson, Laura D Wandner, Esther M Pogatzki-Zahn

Publication

Journal: Pain
Volume: 166
Issue: 11S
Pages: 91 - 94
Year: 2025
DOI: https://doi.org/10.1097/j.pain.0000000000003714

Further Study Information

Current Stage: Completed
Date:
Funding source(s): Gemeinsamer Bundesausschuß (GBA), the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777500 (this Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA), Grünenthal Germany, the DFG, and the BMBF


Health Area

Disease Category: Anaesthesia & pain control

Disease Name: Pain-related diseases

Target Population

Age Range: 18 - 100

Sex: Either

Nature of Intervention: Any

Stakeholders Involved

Study Type

- Commentary

Method(s)