COMET Initiative | Biochemical verification of tobacco use and cessation

Biochemical verification of tobacco use and cessation

No abstract

Aim

The charge of our subcommittee was to assess the utility of biomarkers of tobacco use and cessation and make recommendations for their application in clinical trials.
The committee addressed five specific questions:
1. Which biochemical markers are most useful for assessing tobacco use, with regards to smoking cessation, smoking cessation given other tobacco use, and concurrent use of nicotine medication to aid cessation?
2. What are optimal cut-off points for biomarker values to distinguish tobacco use vs. no tobacco use, with consideration given to data on specificity and sensitivity
at various cut-points and influence of ethnicity?
3. What is an acceptable time window between selfreported last smoking and biochemical verification for different biomarkers?
4. What is the utility (and limitation) of using biochemical markers as indicators of severity of addiction?
5. When is biochemical validation necessary?

Contributors

SRNT Subcommittee on Biochemical Verification*

Publication

Journal: Nicotine Tob Res
Volume: 4
Issue: 2
Pages: 149 - 59
Year: 2002
DOI: 10.1080/14622200210123581

Further Study Information

Current Stage: Not Applicable
Date:
Funding source(s): This work was supported in part by the Society for Research on Nicotine and Tobacco and grant Nos. DA02277 and DA12393 from the National Institutes of Health.

Health Area

Disease Category: Tobacco, drugs, & alcohol dependence

Disease Name: Smoking

Target Population

Age Range: 16 - 100

Sex: Either

Nature of Intervention: Not specified

Stakeholders Involved

Study Type

- Recommendations made

Method(s)

Linked Studies

No related studies