The National Cancer Institute (NCI) Symptom Management and Health-Related Quality of Life Steering Committee convened four working groups to recommend core sets of patient-reported outcomes to be routinely incorporated in clinical trials. The Prostate Cancer Working Group included physicians, researchers, and a patient advocate. The group's process included 1) a systematic literature review to determine the prevalence and severity of symptoms, 2) a multistakeholder meeting sponsored by the NCI to review the evidence and build consensus, and 3) a postmeeting expert panel synthesis of findings to finalize recommendations. Five domains were recommended for localized prostate cancer: urinary incontinence, urinary obstruction and irritation, bowel-related symptoms, sexual dysfunction, and hormonal symptoms. Four domains were recommended for advanced prostate cancer: pain, fatigue, mental well-being, and physical well-being. Additional domains for consideration include decisional regret, satisfaction with care, and anxiety related to prostate cancer. These recommendations have been endorsed by the NCI for implementation.
ContributorsChen, R. C. Chang, P. Vetter, R. J. Lukka, H. Stokes, W. A. Sanda, M. G. Watkins-Bruner, D. Reeve, B. B. Sandler, H. M.
Disease Category: Cancer
Disease Name: Prostate cancer
Age Range: 19 - 100
Sex: Male
Nature of Intervention: Not specified
- Clinical experts
- Patient/ support group representatives
- Researchers
- Systematic review of outcome measures/measurement instruments
- COS Patient Reported Outcomes
- Consensus meeting
- Systematic review